Another Wonder Drug to reverse diabetes on the horizon?
Helps to cancel insulin resistance , especially in Fat people
Yet another promising drug for Type2 Diabetes on the horizon. The hypothesis is attractive
We know that Type 2 diabetes occurs when the pancreas is either not able to produce enough insulin, or the cells of the body simply don’t react to insulin. This is known as Insulin Resistance, which may in turn get blood glucose levels to rise.Insulin Resistance is therefore a major cause for Type 2 diabetes, especially in fat people.
People with insulin resistance have high blood sugar despite normal or above normal levels of insulin in the blood.
Seen in people with excessive body fat (especially in the tummy), insulin resistance is now believed to be mediated through an enzyme: Low Molecular-weight Protein Tyrosine Phosphatase (LMPTP).
The hypothesis is that if we can inhibit LMPTP, we will reduce insulin resistance and can possibly cure Type 2 Diabetes – at least in fat people.
Presently there is no medical treatment available for this condition.
The good news is that a new molecule has been developed by the University of California, and this may be the game-changer to this life threatening condition.
Mice with insulin resistance were given a daily dose of the drug and this reversed the condition.
The type 2 diabetes was effectively “cured”
Scientists had an idea that insulin resistance was caused by a particular enzyme, known as Low molecular weight protein tyrosine phosphatase ( or LMPTP ).
This enzyme is found in the liver and it causes the cells to become resistance to the presence of insulin.
Hence, the scientists felt that LMPTP inhibitors would be a way to cure type 2 diabetes
A study was done where laboratory mice were initially fed a very high fat diet , which caused high obesity and type 2 diabetes in the mice.Then they were given the drug in their diet.
While the drug has no side effects, the cells in the mice once again started to react to the presence of insulin and their sugar levels came to normal levels for at least a month
Before you celebrate, remember that at this stage, results are in mice. The molecule/ drug will first have to be tested in humans for safety (Phase 1 human trials) and subsequently for efficacy, before it is made available in the market. This process can take takes years to decades.
Till then, LMPTP inhibitors remain promising drugs, but in the horizon.